- Platelet Activation:
- Injury stimulates platelets in the blood.
- Platelets release factors crucial for coagulation.
- Tissue Factor Release:
- Injured tissues release specific factors.
- These factors contribute to the initiation of the coagulation process.
- Cascade Process Initiation:
- Cascade process involves a series of linked enzymic reactions.
- Various factors present in plasma in an inactive state become activated.
- Formation of Thrombokinase:
- Enzyme complex thrombokinase is formed.
- Thrombokinase plays a key role in the activation of prothrombin.
- Conversion of Prothrombin:
- Thrombin, an active enzyme, is formed from inactive prothrombin.
- Calcium ions play a critical role in this conversion.
- Fibrinogen to Fibrin Conversion:
- Thrombin converts inactive fibrinogen into fibrin.
- Fibrin forms the network structure of the clot (coagulam).
- Clot Formation:
- The fibrin network traps dead and damaged formed elements.
- Resulting in the formation of a clot at the site of injury.
- Protective Mechanism:
- The entire process is a protective mechanism to prevent excessive blood loss.
- Forms a barrier to seal the wound and promote healing.